INS and Hypoglycemia: As a result of this research effort, commercial applications have started to appear embedded within sensor-augmented insulin pumps (e.g., Medtronic MiniMed 640G with Smart Guard; Tandem t:slim X2TM with Basal-IQ Technology) which have been proven to reduce nocturnal hypoglycaemia by using predictive glucose alerts and a predictive low-glucose insulin suspension system [27,28].