CXCL10 and lobular neoplasia: In one study, urine mRNA transcript of IP-10 performed better than the conventional biomarkers such as 24-h urine protein, creatinine clearance, and urinary sediments in distinguishing class IV LN from other classes of LN with the area under the ROC curve of 0.89 (95% CI 0.78 to 0.99), which had a 73% sensitivity and 94% specificity at the cut-off of 2.09 log copies/μg total RNA [13].