DNMT1 and breast carcinoma: For example, combinatorial treatment with HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) and DNMT inhibitor epigallocatechin gallate (EGCG) down-regulated the oncogenic miRNA-221/222 expression in triple-negative breast cancer cell lines (i.e., MDA-MB-157 and HCC1806) [63] in different breast cancer cell lines.