CD274 and systemic lupus erythematosus: Moreover, whereas blockade with anti-PD-L1 Abs accelerates the onset of LN, PD-1 blockade, in contrast, limits LN and facilitates immunosuppression via both CD4+ and CD8+ Treg cells in NZB/NZW.F1 mice, one of the most widely utilized mouse models of SLE [94,95,96].