Previous studies have further shown that VISTA-knockout mice are more susceptible to EAE [100], whereas both VISTA deficiency and blockade in SLE mouse models promote the activation of splenic CD4+ T cells and myeloid cell populations, resulting in increased pro-inflammatory cytokines, as well as more severe proteinuria and LN [101,102]. The gene discussed is VSIR; the disease is systemic lupus erythematosus.