Additionally, Steevels et al. observed that the ligation of signal inhibitory receptor on leukocytes-1 (SIRL-1), an inhibitory receptor expressed by neutrophils and monocytes, suppresses the release of NETs in SLE [231], and this inhibitory phenomenon was also found in both spontaneous and antibody-induced NETosis from neutrophils from SLE patients [232]. Here, VSTM1 is linked to systemic lupus erythematosus.