PPARG and amyloidosis: Despite the fact that functional studies have demonstrated that ApoE expression induced by RXRs:LXRs or RXRs:PPARγ contributes to acceleration of β-amyloid clearance (Cramer et al., 2012;Jiang et al., 2008;Escribano et al., 2010), under the experimental conditions in the present study, there were no apparent associations between amyloid clearance and ApoE overexpression in regions as CA1 or between amyloid clearance and soluble β-amyloid reduction in the cortex.