AIF1 and Alzheimer disease: Iba1 staining showed significantly greater intensities in the DG, CA1 and CA3 areas of the hippocampus and in the entorhinal cortex (Ent-Cx) of untreated 3xTg-AD mice than in those of the control WT animals (p < 0.01, p < 0.001, n = 4), but significantly less Iba1 staining was found in the DG, CA3, Cx and Ent-Cx of bexarotene-treated 3xTg-AD mice than in those areas in untreated 3xTg-AD animals (p < 0.05, n = 4) (Fig 4).