For example, the lncRNA, nuclear paraspeckle assembly transcript 1 interacted with miR-101 to modulate breast cancer growth by targeting EZH2 [10]; the lncRNA, SPRY4 intronic transcript 1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cells through up-regulating EZH2 [11]. This evidence concerns the gene EZH2 and breast carcinoma.