Consistent with the low expression of DTX2 and high expression of HSF2 in cluster2 (Figure 4D), DTX2 was highly expressed in docetaxel, cisplatin and PIK-93 resistant colon cancer cells (Figure 4F), while, HSF2 was highly expressed in docetaxel, cisplatin and PIK-93 sensitive colon cancer cells (Figure 4G). Here, HSF2 is linked to colonic neoplasm.