The following variables were significantly associated with the IL‐18 concentration at three out of the four occasions during follow‐up: male sex, obesity, diabetes and biomarkers of renal function (cystatin C), and inflammation (WBC, CRP‐hs, GDF‐15, Il‐10) (Table S1). The gene discussed is CST3; the disease is obesity due to melanocortin 4 receptor deficiency.