IL18 and coronary artery disorder: Interleukin‐18 (IL‐18), a member of the IL‐1 cytokine superfamily, is a pleiotropic inflammatory cytokine expressed in several cells including macrophages and endothelial cells.5 Increased circulating IL‐18 concentrations have been associated with coronary artery disease and an increased risk for cardiovascular (CV) morbidity and mortality.6, 7 IL‐18 has been detected in atherosclerotic plaques and has been proposed to destabilize coronary plaques leading to subsequent thrombotic events.3 Nonetheless, the importance of circulating IL‐18 in patients with ACS is not well documented.8