ITGAX and B-cell chronic lymphocytic leukemia: While both dendritic cells (DCs) and macrophages can sequester pathogens in the liver (Jenne and Kubes, 2013), treatment of mice with CLL resulted in depletion of F4/80+ liver macrophages (Figure 2E, Figure 2—figure supplement 1 and Figure 2—figure supplement 2) but had minimal impact on CD11c+ DCs (Figure 2—figure supplement 2), suggesting macrophages are responsible for alphavirus clearance.