At 36 h after infection, however, lung bacterial loads were approximately 100‐fold lower in PKK ASO‐treated mice relative to Ctrl ASO‐treated animals (p < 0.01); similarly, bacterial loads in blood, spleen, and liver were also 10‐ to 100‐fold lower in PKK ASO‐treated mice (p < 0.01 to p < 0.05). The gene discussed is KLKB1; the disease is infection.