Indeed, in general, early stimulation of innate immunity in the lung is associated with an improved defense against respiratory pathogens in pneumonia models 34, and specific pathways induced by PKK ASO administration such as pattern recognition receptors 39, 40, TREM‐1 signaling 41 and interferon signaling 42, 43 have been implicated in protective immunity during Klebsiella pneumonia (supplementary material, Figure S8). Here, KLKB1 is linked to Klebsiella pneumonia.