This is in agreement with cell culture study which reported that only a long‐term statin exposure could induce cell apoptosis, G1 cell cycle arrest, autophagy, and degradation of androgen receptors.28 If statins impact PCa risk via the action on lipid metabolism, lipophilicity of statins may be important in determining their cancer‐preventive capability.29 In the current study, we only found a significant protective association of lipophilic statins with PCa risk. Here, AR is linked to cancer.