POLK and central nervous system cancer: Similarly, previous studies demonstrated that extend of resection and chemotherapy played protective roles in glioma.29, 30, 31 As for the prognostic value of POLK SNPs in glioma, a similar study by Shao et al. showed no significant associations between POLK SNPs (rs3213801 and rs5744533) and patient prognosis in NSCLC.18 Consistent with the above findings, we failed to identify statistically significant differences between genotypes of POLK SNPs and survival of glioma patients.