Meanwhile, compared with patients harboring the CC genotype, the CT and CT+TT genotypes of POLK rs5744533 were increased in the patients with lower WHO grade glioma (CT vs CC: OR = 0.67, 95%CI: 0.47‐0.96, P = .028; CT+TT vs CC: OR = 0.71, 95% CI:0.51‐0.99, P = .044) (Table 3). Here, POLK is linked to central nervous system cancer.