In agreement with elevated hepatic steatosis, mRNA expression of hepatic perilipin (Plin), a gene promoting lipid droplet formation and known to be elevated in fatty livers (Trevino et al, 2015), was significantly increased in HFD‐fed ASK1Δhep compared with ASK1F/F mice (Fig 3C). This evidence concerns the gene PLIN1 and fatty liver disease.