Some of the most recently recognized hepatokines involved in NAFLD pathogenesis are Fetuin-A, fibroblast growth factor 21 (FGF-21), selenoprotein P (SEPP1), sex hormone-binding globulin (SHBG), angiopoietin-related growth factor, and leukocyte cell-derived chemotaxin 2 (LECT2). The gene discussed is LECT2; the disease is metabolic dysfunction-associated steatotic liver disease.