AQP4 and Alzheimer disease: At present, many studies have shown that the deposition of β-amyloid peptide (Aβ) and neurofibrillary tangles (NFTs) are the main pathological changes in Alzheimer's disease [3-6], while apolipoprotein E4 (ApoE4), α-synuclein (α-Syn), aquaporin-4 (AQP4) and hyperphosphorylated tau play important roles in the process of Aβ deposition and NFTs [7-13].