TNFSF11 and osteoporosis: On the other hand, calcitriol or some calcitriol analogues such as eldecalcitol (1α,25-dihydroxy-2β-(3-hydroxypropoxy) vitamin D3) or alfacalcidol (1α(OH)D3) are used in the treatment of osteoporosis because they increase bone mineralization by reducing bone resorption [61,62] through the suppression of RANKL expression in osteoblasts and decreased osteoclastogenic potential, as shown in eldecalcitol- or alfacalcidol-treated mice [63,64].