Previous works showed that ADCY6 was also related to the myocardial hypertrophy, blood pressure or hyperdynamic cardiovascular response, suggesting that it played a crucial role in cardiovascular diseases.37, 38 Taken together, both miR-17-3p and ADCY6 were linked with the cardiovascular illness but this was the first time showing that they affected the cardiac function via Ca2+. The gene discussed is ADCY6; the disease is cardiac hypertrophy.