HIPK3 and myocardial infarction: Results of echocardiography showed hearts in experiment group had a better cardiac function in relative to that in NC group, and they also had a reduced infarct area evidenced by TTC staining (Triphenyltetrazolium Chloride).(Figure 5B-D) Consistently, the degree of heart fibrosis in NC group was much higher than that in experiment group.(Figure 5E) The above results suggested that AAV9-shRNA targeting circ-HIPK3 could partly alleviate the heart remodeling post MI and further maintain the cardiac function in vivo.