Apart from affecting Ca2+ in cell, miR-17-3p also can promote proliferation of cardiomyocytes in rat or mice to compensate the cardiac function via targeting metallopeptidase inhibitor 3 (TIMP3) or regulators of the PTEN-AKT pathway.35, 36 So, this might be another explanation of circ-HIPK3 associated with the mortality of HF. This evidence concerns the gene HIPK3 and hydrops fetalis.