mTORC2 inhibition also reduces cell motility and survival in cultured human breast cancer cell lines10, 18, 19.Clinical studies have shown that invasive breast carcinomas (IBCs)express more Rictor compared with normal breast epithelium, which suggeststhat Rictor level is correlated with higher grade (grade II/III) breast tumors17. This evidence concerns the gene RICTOR and invasive breast carcinoma.