To explore the influence of Rictor ablation in BMSCs onTM40D-induced bone destruction, TM40D breast cancer cells were injected intratibially intoPrx1-Cre; Rictorf/f(hereafter RiCKO) mice or Rictorf/f mice (as controls), to construct a breast cancer bone metastasis model. This evidence concerns the gene RICTOR and breast cancer.