In accordance with the radiological data, the immunohistochemical staining of collagen-I and histochemical staining of total collagen confirmed that bone mass was greater in the metastatic sites of RiCKO mice (Fig. 1D,E).These results indicated that Rictor ablation in BMSCs inhibited cancer-induced osteolytic lesions and maintained greater bone volume. Here, RICTOR is linked to cancer.