A previous study demonstrated that a SEC23B mutation causes congenital dyserythropoietic anemia type-II (CDAII) 4, while the SEC23A mutation causes cranio-lenticulo-sutural dysplasia (CLSD) due to abnormal endoplasmic-reticulum-to-Golgi trafficking 5. The gene discussed is SEC23A; the disease is congenital dyserythropoietic anemia type 2.