We also analyzed the expression of FZD2 in the Oncomine database using unbiased bioinformatics (http://www.oncomine.org), and we found that FZD2 is upregulated in 10 head and neck cancer datasets and is not downregulated in any dataset when the threshold was set as P=0.05, Fold Change=1.5, and Fig 1D shows some representative images of FZD2 overexpression. The gene discussed is FZD2; the disease is head and neck cancer.