We further analyzed the data and determined that FZD2 was significantly increased in head and neck squamous cell carcinoma and tongue cancer compared with normal tissues (Fig 1B); moreover, the overall survival of patients with head and neck squamous carcinoma with high FZD2 expression (n=194, FPKM>means) was significantly decreased (Fig 1C, P=0.02) when compared FZD2 low expression (n=307, FPKM<means). Here, FZD2 is linked to head and neck squamous cell carcinoma.