IGF2BP3 has been also reported as biomarker with clinical relevance in different type of cancers including Glioma, colorectal, lung, liver, and breast cancer 32; accumulating evidence also demonstrated this gene role in pancreatic cancer with the perspectives of migration, invasion, and adhesion as well as IGF2BP3-mediated translation in cell protrusions 33, 34. This evidence concerns the gene IGF2BP3 and central nervous system cancer.