AKT1 and Familial prostate cancer: Chen and the team found that the overexpression of INPP4B (a phosphatidylinositol signalling pathways involved enzyme) can suppress the invasion, migration, and angiogenesis of prostate cancer, they also were able to show INPP4B reversed docetaxel resistance and EMT (epithelial to mesenchymal transition) through PI3K/Akt pathway 29, 30.