Several cancer-related networks were found to be up regulated in high risk score cases including cell cycle/DNA replication, cancer microenvironment, Hypoxia metagene associated pathways/HIF1 pathway and some therapeutic targets correlated signalling such as RAS, ERBB1/2/4, PI3K PLC TRK, IGF1, mTOR, TGF-b receptor, HDAC1/2 targets, and CDH1 associated pathways (Figure 6A-D, Table S5). Here, IGF1 is linked to cancer.