It is plausible that proper dose of arsenic chelating agents such as BAL, DMPS, and DMSA57 or overexpressing arsenic-sequestrating proteins such as Hexokinase-2 (HK2)58 in BAT would be beneficial in improving lipid metabolism, mitochondrial function and thermogenesis, which contribute on the prevention or treatment of arsenic-induced metabolic disorders. This evidence concerns the gene HK2 and metabolic disease.