F8 and hemophilia A: The scope of our studies sought to model the observed clinical association of severe deficient factor VIII and bone abnormalities in males with hemophilia A. Using dual energy X-ray absorptiometry (DXA) and microcomputed tomography (microCT) measurement we found that in the absence of any observed injury or bleeding FVIII−/− mice display significantly low bone mineral density (BMD) and other deficits of trabecular bone integrity.