There was a high prevalence of anti-dsDNA, anti-nucleosome, anti-Ro, anti-La, and anti-Sm IgG autoantibodies across the entire SLE cohort (area under the curve [AUC] > 0.75, P < 0.001) and within each manifestation (AUC > 0.70, P < 0.05) compared with healthy donors. The gene discussed is SSB; the disease is systemic lupus erythematosus.