APP and Alzheimer disease: A significant number of genes were unique to each of the models; however, significant overlap was observed between both AD models and with genes altered with aging (APP:Aging χ2p < 2.2 × 10−16; CK-p25:Aging χ2p < 2.0 × 10−14; APP:CK-p25 χ2p < 2.2 × 10−16) (Fig. 6a).