First, we found expression of another polyQ protein, ATXN3Q78, involved in Machado-Joseph disease [64, 65] and a mutant form of Tar Domain Protein 43 (TDP43-A315T), which is involved in a familial autosomal dominant form of amyotrophic lateral sclerosis [66, 67] in PDF neurons results in a robust reduction in overall rhythmicity. The gene discussed is TARDBP; the disease is Machado-Joseph disease.