CD4 and Autoimmunity: In 2012, R. Haque et al showed that the transduction of FOXP3 during the differentiation of IPSC into T cells led to the production of functional CD4+FOXP3+ Tregs in mice.172 Indeed, these CD4+FOXP3+ Tregs derived from IPSC were able to secrete suppressive molecules such as IL‐10 and TGFβ and they controlled autoimmunity in an arthritic mouse model.