INS and obesity due to melanocortin 4 receptor deficiency: A previous report revealed that children of mothers with obesity tend to be 2.6 times more obese than children with nonobese mothers.[29] Weight gain during pregnancy has been reported to affect maternal insulin resistance and hormonal secretion in the womb and obesity in postnatal infants.[20] Therefore, it is important to provide guidance about appropriate weights during pregnancy for the prevention of childhood obesity or maternal lifestyles for the acquisition of appropriate lifestyle since early childhood.