Usually, mediate to large dosage of glucocorticoid as well as immunosuppressive agents should be administered, and laboratory tests such as CRP, ESR, hemoglobin, and other auxiliary examinations like endoscopy and CT should be reviewed.[14] The medication dosage should be reduced gradually and according to patients’ follow-up results, relevant medical measures such as PPI or surgery should be conducted, if peptic ulcer or aneurysm is discovered. This evidence concerns the gene ESR1 and aneurysm.