In theory, the increase of blood pH increases the cellular response to insulin, but there is no evidence that an infusion of sodium bicarbonate can accelerate the recovery of patients and reduce the days of hospitalization.[3] Kraut and Madias[4] have observed that in patients who suffered ketoacidosis and when the blood pH <7.1, along with complications of prolonged hypotension and cardiovascular system symptoms (such as arrhythmia), the administration of insulin and fluid therapy does not work, and 5% sodium bicarbonate can be used to maintain the blood pH value above 7.2. This evidence concerns the gene INS and Arrhythmia.