This variant has been reported as a pathogenic variant in individuals with breast cancer and Fanconi anaemia.21, 22, 23 Similarly, a recent case report24 described a patient with metastatic pancreatic neuroendocrine carcinoma with a rare germline pathogenic frameshift variant in exon 5 of the PALB2 gene denoted as c.2325dupA, p.Phe776Ilefs*26. Here, PALB2 is linked to breast cancer.