In NB cell lines SH‐SY5Y, SK‐N‐AS, IMR‐32, and BE(2)‐C, colon cancer SW480 cells,13 and cervical cancer SiHa cells14 (representing low or high MZF1 levels), stable overexpression or knockdown of MZF1, respectively, increased and decreased the expression of ALDH18A1 and PYCR1 (Figure 1D,E; Figure S1B–F, Supporting Information), two genes essential for proline synthesis and tumor progression.15, 16 Meanwhile, the expression of ODC1, SLC7A5, and VARS was not affected by ectopic overexpression or silencing of MZF1 (Figure 1D,E; Figure S1C,D, Supporting Information). Here, PYCR1 is linked to malignant colon neoplasm.