NF1 and neurofibromatosis type 1: Neurofibromatosis type 1 (NF-1) is a rare autosomal dominant disease that affects approximately 1 in 3,500 people.1 Clinical symptoms of NF-1 include a variety of cutaneous and skeletal abnormalities such as freckling and café-au-lait macules, multiple neurofibromas, and scoliosis.