LEP and neoplasm: An explanation to such contradictory report might lie in the fact that LEPR shows polymorphism and phenotypic variants (Aloulou et al., 2008; Mu et al., 2014; Uchiyama et al., 2011; Uddin et al., 2009b) and it is very much possible that different variants respond differently to LEP stimulation—one variant might over-stimulate cells towards carcinogenesis, while another might be less sensitive to circulating LEP concentration or even act against the progress of the tumor.