LEP and colonic neoplasm: However, the claims by various authors about the effect of LEP-LEPR system in colon cancer are confounding, and maybe even contradictory (Hoda et al., 2007; Uchiyama et al., 2011; Stattin et al., 2003; Stattin et al., 2004; Bolukbas et al., 2004; Kumor et al., 2009; Sălăgeanu et al., 2010; Kosova et al., 2013).