The over-expression of LEPR, as we found in one of our previous studies with breast cancer (Al-Shibli et al., 2017), and by many authors with various cancers (Aloulou et al., 2008; Ishikawa, Kitayama & Nagawa, 2004; Mu et al., 2014; Uchiyama et al., 2011; Uddin et al., 2009b; Jardé et al., 2008; Miyoshi et al., 2006; Uddin et al., 2009a; Hoon Kim et al., 2008) must be significant in the carcinogenic influence of obesity or LEP. Here, LEPR is linked to obesity due to melanocortin 4 receptor deficiency.