Although it has been reported that the level of LRSAM1 is significantly increased in patients with colorectal cancer and can be downregulated by pectolinarigenin (PEC), a natural flavonoid from citrus fruits with antitumor effects in human gastric cancer cells [26, 27], the role of LRSAM1 in HCC remains unknown. The gene discussed is LRSAM1; the disease is hepatocellular carcinoma.