In summary, we reported CCNB1 and CCND1 were overexpressed to accelerate cell cycle in seminal vesicle tumors of TRAMP mice from 24 weeks old or so, which might be regulated by EGFR-AKT signaling pathways through oncoprotein transformation of P21 and P27 when P53 has no anti-tumor activity. The gene discussed is TP53; the disease is neoplasm.