We found AKT and its upstream EGFR were increased in seminal vesicle tumors of TRAMP mice from 24 weeks of age, so were their phosphorylated levels, which might result in oncogenic transformation of P21 and P27 to promote cell proliferation and tumor growth via cell cycle acceleration in WT P53-null seminal vesicles of TRAMP mice. The gene discussed is TP53; the disease is neoplasm.