Conversely, other groups reported that let-7f reduced the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration 60; inhibited glioma cell proliferation, migration, and invasion 61; inhibited cisplatin resistance induced by secreted protein acidic and rich in cysteine (SPARC) in medulloblastoma cells 62; was downregulated in hepatocellular carcinoma 63 and papillary thyroid cancer 64; and inhibited tumour invasion and metastasis in human gastric cancer 65. This evidence concerns the gene SPARC and central nervous system cancer.