Let-7f-5p is reported to promote chemotherapeutic resistance in colorectal cancer 57, was stable or overexpressed in the majority of typical and atypical lung carcinoid samples analysed 58, and contributed to downregulation of thrombospondin-1 in breast cancer with low-dose metronomic paclitaxel chemotherapy 59. The gene discussed is THBS1; the disease is breast carcinoma.