PSEN2 and Alzheimer disease: In the AD's pathway, 12 genes were taken from our results, including the ADAM metallopeptidase domain 10 (ADAM10), LDL receptor related protein 1 (LRP1), amyloid beta precursor protein (APP), apolipoprotein E (APOE), beta-secretase 1 (BACE1), cyclin dependent kinase 5 (CDK5), microtubule associated protein tau (MAPT), insulin degrading enzyme (IDE), presenilin 1 (PSEN1), presenilin 2 (PSEN2), synuclein alpha (SNCA) and tumor necrosis factor (TNF).