Although, some results have suggested that KDM3B mediates H3K9 methylation, which plays important roles in AML development, progression and prognosis, due to the lack of global information on KDM3B and H3K9 methylation status of chromatin, the mechanisms of H3K9 methylation mediated by KDM3B in hematopoietic malignance development are not known [22–24]. This evidence concerns the gene KDM3B and acute myeloid leukemia.