Recently, the literature in ccRCC reported the upregulation of RUNX1- RUNX1 partner transcriptional co-repressor 1 (RUNX1-RUNX1T1) gene signatures, the fusion transcript between the RUNX1 gene and the RUNX1T1 locus because of t(8;21)(q22;q22) (Metzeler & Bloomfield, 2017), which was revealed by RNA sequencing (Xiong et al., 2014). Here, RUNX1 is linked to nonpapillary renal cell carcinoma.