As showed in the Table 2, the univariate analysis described that tumor stage, tumor grade and low EFEMP2 expression significantly affected OS in BCa patients, after incorporating these factors into multivariate analysis, it described that tumor stage (HR: 2.199; 95% CI, 1.158-4.175; p=0.016) and low EFEMP2 expression (HR:1.962; 95% CI, 1.004-3.833; p=0.049) impacted the OS. This evidence concerns the gene EFEMP2 and neoplasm.