The univariate analysis also represented that tumor stage, tumor grade and low EFEMP2 expression interfered MFS in BCa patients, and the multivariate analysis revealed that the tumor stage (HR: 1.950; 95% CI, 1.030-3.691; p=0.040) and low EFEMP2 expression (HR:2.065; 95% CI, 1.062-4.016; p=0.033) were still independently associated with MFS. This evidence concerns the gene EFEMP2 and neoplasm.