EFEMP2 and neoplasm: And as presented in the Table 3, the univariate analysis also showed that tumor stage, tumor grade and low EFEMP2 expression were the obvious prognostic factors for PFS, and the multivariate analysis demonstrated that tumor stage (HR: 2.684; 95% CI, 1.615-4.460; p<0.001) and low EFEMP2 expression (HR:2.206; 95% CI, 1.243-3.915; p=0.007) were the independent prognostic factors of PFS.