EFEMP2 and osteosarcoma: Zhang et al. 23 revealed that the expression of EFEMP2 was obviously upregulated in osteosarcoma samples and strong-invasive-ability cell lines, but not in normal tissues and weak-invasive-ability cell lines, and EFEMP2-overexpressing osteosarcoma cells obtained an increased proliferation, invasion and metastasis capability by enhanced the EMT process.