Stabilization of p53 is essential for its tumor suppressor function.50 Activation of PI3K/Akt signaling negatively controls p53 levels through promotion of Mdm2 movement in the nucleus.51 Mdm2 is an oncoprotein regulating the p53 protein levels and transcriptional activation through ubiquitin ligase activity.22 PTEN inhibits activation of PI3K/Akt signaling, prevents translocation of Mdm2 in the nucleus and positively regulates p53. This evidence concerns the gene MDM2 and neoplasm.