PTEN–p53 associations demonstrated their dependence on each other in tumor suppression activity.56 We illustrated inhibition of PI3K/Akt signaling with BKM-120 and MK-2206 inhibitors upregulated PTEN gene and increased PTEN protein phosphorylation, whereas total PTEN protein levels did not change significantly. The gene discussed is AKT1; the disease is neoplasm.