Also previous research showed that wortmannin, a PI3K inhibitor, by mimicking PTEN function and enhancing of P53 stability, could induce sensitization to treatment with p53-inducing drugs in refractory tumors with wt p53.44 Silva et al demonstrated that LY294002 treatment was not affective against T-ALL patient samples with normal levels of PTEN expression, PTEN phosphorylation, and PI3K/Akt pathway activation, whereas other PTEN-expressing samples showing PI3K/Akt pathway hyperactivation were sensitive to LY294002 treatment. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.