Additionally,both inhibitors, particularly in combination with each other, increased apoptosis (evaluatedwith Annexin V and caspase 3) and reduced proliferation (Ki67 expression) in leukemia cells.However, administration of IL7 downregulated PTEN and P53 mRNA expression and rescuedcancer cells following inhibition of BKM-120 and MK-2206. The gene discussed is PTEN; the disease is leukemia.