CASP3 and breast cancer: Furthermore, all the patients reverted to regular menstrual cycles after 12-month treatment.41 Glab also exhibited cytotoxic and estrogenic and anti-proliferative activity toward human breast cancer cells.42 Licorice and its other isolates, including 18-β glycyrrhetinic acid exhibited anti-proliferative effect on human epithelial ovarian carcinoma cells, leading to a decreased Bcl-2 level and up-regulated cytosolic and mitochondrial Bax protein expression, and activated caspase-3.43-45