BCL-2, MCL-1and BCL-XL have been identified as three important factors in this pathway.17 BCL-2 family plays a key role in regulation and inhibition of apoptosis and increase in its activity gives rise to a wide spectrum of cancers.18 Reduction in BCL-2 gene expression is the hallmark of the beginning of apoptosis which reinforces the effects of anti-tumor therapy. The gene discussed is BCL2; the disease is cancer.