The Japanese Society of Hepato‐Biliary‐Pancreatic Surgery developed the Tokyo Guidelines in 2007 to diagnose and grade the severity of acute cholecystitis based on local clinical signs (Murphy's sign, right upper quadrant mass, pain and gallbladder tenderness), systemic signs of inflammation (fever, raised C‐reactive protein (CRP) level and increased white cell count (WCC)) and imaging findings1. The gene discussed is CRP; the disease is Cholecystitis, Acute.