The Cox proportional hazard model further demonstrated that quartile level of C4CV independently predicted (HR, 1.26; 95% CI, 1.18–1.35 per quartile increase) the composite endpoint of microvascular events after adjusting for age, gender, smoking, systolic blood pressure, diastolic blood pressure, dyslipidemia, diabetes duration, EGFR, Hba1c, and cardiovascular disease history. This evidence concerns the gene EGFR and metabolic syndrome.