P2RY1 and obesity due to melanocortin 4 receptor deficiency: In light of the potential modulatory role for PKD1 phosphorylation on serine 916, it is therefore intriguing to speculate that the FFA receptor GPR40 and autocrine P2Y1 signaling may exert synergistic effects via PKD1 when FFAs are elevated in high‐fat diet (Bergeron et al. 2017) or human obesity.