However, an increasing number of studies point out the “dark side” of FOXO3 and describe its potential oncogenic properties in different cancer types, including chronic myeloid leukemia (CML), acute myeloid leukemia (AML), breast cancer, glioblastoma, and pancreatic cancer [4–17]. Here, FOXO3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.