FOXO3 and neuroblastoma: We found that FOXO3-mediated activation of the DEPP-promoter, a direct transcriptional target gene of FOXO3 in NB cells [38], was repressed by CBX treatment in a dose-dependent manner as shown by a DEPP-promoter reporter assay (Fig. 3a) and by a chromatin immunoprecipitation experiment (Fig. 3c).