To identify alterations of AN at early prodromal stages of AD, we measured the proliferative rate of SVZ NSCs by in vivo BrdU labeling in 1.5-month-old APP Tg2576 mice, which represent a slow progressive AD model developing amyloid-beta (Aβ) plaques around 9–13 months of age [26, 27], with the earliest synaptic and learning deficits observed at 3 months of age [28]. This evidence concerns the gene APP and Alzheimer disease.