In addition, TPGS was shown to induce apoptosis in T cell acute lymphocytic leukemia cells (but not on human peripheral blood lymphocytes) in a dose dependent manner; TPGS increased the expression of Bax and Puma, reduced mitochondrial membrane potential, caused Caspase-3 cleavage, nuclear DNA fragmentation and cell cycle arrest in ALL cells50. The gene discussed is CASP3; the disease is acute lymphoblastic leukemia.