BIRC5 and cancer: YM155 (Sepantronium bromide) (Fig. 1A), is a potent small-molecule suppressant of Survivin that induces DNA damage and apoptosis in various human cancer models10.YM155 suppresses Survivin expression by binding to the C-terminal of RNA binding proteins interleukin enhancer-binding factor-3 (ILF3/NF110) and disrupts its binding to the Survivin promoter.